A Paradigm Shift In Treating EDSPOTS – Dr Katinka

Researchers have identified four types of histamine receptors: 1.​ H1 receptors: Present throughout the body, including in blood vessels, brain cells, and airways. May cause itching, pain, decreased blood pressure, flushing, and, in severe cases, anaphylaxis. H1 receptors also regulate sleep, food intake, emotions, memory, and body temperature. 2.​ H2 receptors: Mainly in the stomach in cells responsible for releasing stomach acid, but also present in the heart and muscle cells. Causes headaches, fast heartbeat, decreased blood pressure, and the release of stomach acid. 3.​ H3 Receptors: Primarily involved in the function of your blood- brain barrier.

They’re found in neurons in your CNS. They regulate the release of histamine and neurotransmitters (dopamine, acetylcholine, and norepinephrine). 4.​ H4 receptors: Present in your bone marrow and special blood cells called hematopoietic cells. These immature cells can develop into different blood cells. They play a role in autoimmune and inflammatory conditions.

At least one study has linked histamine intolerance to EDS.36 The EDS, POTS, and MCAS are all linked by a gene duplications and triplications in a gene called the TPSAB1 gene, responsible for encoding α-tryptase.37 Mast cells release histamines. In the last two decades, there has been a particular increase in evidence to support the involvement of H3 and H4 receptors in the modulation of neuropathic pain. In the peripheral nervous system, histamine is released in response to tissue injury and/or damage.

Through the sensitization of nociceptors (sensory receptors for painful stimuli), histamine may cause increased firing rates, contributing to pain hypersensitivity. In neuropathic pain, histamine released in the periphery by mast cells has been shown to play an important role in the development of hypersensitivity following nerve injury. We have now established a connection between POTS/EDS patients, increased histamine, the connection of histamine to nerve pain, and histamine intolerance in EDS patients.

It all leads to neuropathic pain. Why does your body respond violently to changes in the weather? When patients suffer from central pain syndrome (CPS), their nervous systems undergo anatomical and chemical changes. In CPS, nociceptors (tiny pain receptors) and peripheral nerves become hypersensitive. Pain amplification in the spinal cord tends to increase, and the spinal cord’s ability to filter pain decreases.

This book is dedicated to you. The ignored. The mistreated. The under-diagnosed. The puzzle. The medical unicorn. You are my why 1kitap1.com/en Table of Contents Disclaimer Foreword My Story Chapter 1​ The Basics: EDS/POTS Chapter 2​ The Emotional Impact of Invisible Disease Chapter 3​ Understanding the EDS Types Chapter 4​ Thinking Outside the Box: Traditional Diagnoses and Treatment of EDS/POTS, and How It Is Failing Patients Chapter 5​ Beyond Joints: EDS/POTS and the Impact of Abnormalities of Connective Tissue (Meninges, Digestive System, and Blood Vessels) Chapter 6​ Pain, Your Constant Companion Chapter 7​ The (Other) Common and Uncommon Symptoms Associated With EDS/POTS Chapter 8​ Pandora’s Box: Does Your Genetic Code Doom You Chapter 9​ The Role Your Nervous System Plays Chapter 10​ As If EDS/POTS Is Not Enough: Coexistent Conditions ​ Amplified Pain Syndrome (AMPS) ​ Anxiety ​ Arnold Chiari Malformation ​ Complex Regional Pain Syndrome (CRPS) ​ Fibromyalgia ​ Functional Neurologic Disorder (FND) ​ Gastroparesis and Other GI Disorders ​ IInterstitial Cystitis (IC)/Urinary Tract Infections (UTIs)/Bladder Issues ​ Median Arcuate Ligament Syndrome (MALS) ​ Mast Cell Activation Syndrome (MCAS) ​ Headaches and Migraines ​ Long COVID ​ Small Fiber Neuropathy (SFN) Chapter 11​ Supplementing for Your Health: What to Eat, What to Take Chapter 12​ The Role of Viral/Bacterial Infections Chapter 13​ Real Patient Stories Chapter 14​ Hang On, Pain Ends Quotes References 1kitap1.com/en Disclaimer The information written in this book is designed to provide helpful information on EDS/POTS and the subjects discussed.

This book is not meant to be used to diagnose or treat any medical condition or to replace the advice of your physician(s). The author of this book does not claim to treat, diagnose, or cure EDS/POTS or any other specific condition or infection. The author of this book treats the central nervous system only, often resulting in the body being able to heal itself. The reader should regularly consult a physician in matters relating to his or her health, particularly with respect to any symptoms that may require diagnosis or medical attention.

For diagnosis or treatment of any medical problem, consult your own physician(s).

This is a short excerpt from the opening of “” by Unknown, quoted for review and introduction purposes. All rights belong to the copyright holders.

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